Showing posts with label tales from the field. Show all posts
Showing posts with label tales from the field. Show all posts

Monday, July 26, 2010

Blue skies and bike seats

Image of pigeons wheeling, silhouetted, after afternoon prayers, above the Jama Masjid in the old town of New Delhi against an impossibly blue and bright sky.
Dear Gentle Reader,

Blue skies are apparently ahead.

Which would be good, as storm clouds have raged, or, worse, droned for a while.

For anyone who actually ever checks over here, yet another mea culpa.

The past couple of years have been a bit trying, medically, as interesting diagnoses come and go.

Parkinson's disease one day.

Multiple sclerosis, another.

Fortunately, both of those were rejected after extensive testing.

Unfortunately, the underlying conditions were ultimately described as a syndrome; diagnostic shorthand for "we know what symptoms you present, and they are real, but we have no idea what the underlying cause is, or how, ultimately, to treat you".

Great.
Really.

I really didn't want Parkinson's, or MS, true.

And I really didn't want the underlying conditions, either.

Another set of conditions were ultimately resolved in a similar way--by calling them a syndrome, again.

Which was all sort of fine.
Ish.

Until, rather recently, there was another concern.

Doctors thought that I might have pancreatic cancer.

And pancreatic cancer is really not good.

Whilst life is terminal (we ride a sinking boat from birth, to paraphrase some Buddhists), pancreatic cancer tends to accelerate the submersion like a torpedo hitting amidship.

Pancreatic cancer led to an extensive pharmacological diet aimed at whacking me in the belly--amidship my ship.

Now, for your humble scribe, pharmacological diets can be rather interesting, and not just amidship. My upper decks and command centres take hits of their own.

Fermented sugar, alone, has interesting effects while stronger pharmawonders tend to bend the hues of the spectrum and provide organic whammy bars to your humble scribe's sensory interpretation systems...

(Your humble scribe hallucinates, visually and aurally (hypnogogic hallucinations), upon taking Tylenol 3s, which my Southern Cousins would call Tylenol with Codeine... ...most people take Tylenol 3s with much less ado simply for pain relief.)

...But, my big pharma anti-pancreatic cancer diet held new combinatorial side-effects for my pleasure and enjoyment...

...such as autodigestion of my cartilage and tendons...
(...mmm...)

...and total-body tendonitis...
(...woohoo).

And then, just before I took off to India, I was told that pancreatic cancer was not, in fact, a concern.

Presumably a new syndrome diagnosis will be offered to me to replace the diagnosis taken away from me but, again, I am rather fine with this.

I still have a pharma diet, which is a much reduced pharma diet from my 'peak', which is good (ish) though I've only managed two non-pharma meals in the last seven days...

(And yet those love handles still persist!)

(...Do you actually have to want to be an ascetic (rather than being forced into asceticism) to get those sveltish lines of Siddhartha Gautama, post his "Great Departure" (when he left his Father's kingdom, and luxury, to live life as an ascetic)?)

Anyway.

All this is by way of an explanation for my absence, as I had promised a few people that I would write, ages ago.

And then broke those promises.

Now you know why.

Anyway, enough whining.

I've been gone a rather long time; I am trying to get back onto the saddle.

Image of a great, red with huge yellow polka-dotted bicycle saddle found in Bhubaneshwar, Orissa (India).



I hope to write more soon, and maybe even read.

Till then...


Tschuess,
Chris



Click to hear The Be Good Tanya's 'The Littlest Bird' from their album 'Blue Horse'

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Friday, December 18, 2009

On poison, fugu, pufferfish, and tetrodotoxin

An image of a porcupine fish used as a lantern at your humble scribe's abode, entitled 'Death incarnate. Or his cousin.'.Dear Gentle Reader,

You're back!

I wasn't sure you'd return.

Care for some wine?

A taste of the goodness in Borgia's cup, perhaps?

No, today there will be no drinking. We don't want to gag.

Only solid(ish) food, today.

And a tale from the field.

Monday's image was a close-up section of today's image which shows a lantern in your humble scribe and Heroine's home, made from a fish.

This fish is not the fabled fugu, the pufferfish.

This is its cousin, the porcupine fish, a blowfish.

Both fish blow or puff themselves up, but blowfish have huge, very conspicuous spines studding their body, whilst pufferfish have much smaller, more slender, delicate spines.

Both, mind you, are well-equipped, internally, with tetrodotoxin, sometimes known as TTX.

Tetrodotoxin, C
11H17N3O8, has a really fancy IUPAC name:
Image of tetrodotoxin, TTX, sourced from the Wikimedia Commons; in the public domain.Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol.

Try dropping that in conversation.

Just don't drop it in the wine. Or in the food.

Unless you want to best the Borgia's and their relatively tame cantarella, by comparison, at least.

There is no known antidote to TTX; no known cure. And the puffer fish, specifically Takifugu rubripes, the torafugu, is the second-most poisonous vertebrate on planet Earth.

What does tetrodotoxin do?

Well, it's a bit like that hemlock that Socrates drank.

TTX paralyzes you and then you drown in the fluid that accumulates in your lungs.

But, TTX does so much more than that. It shuts everything down, except that, usually, you are lucid right until the end. Although you might feel a floaty sensation and a few other tricks of the mind.

TTX is a neurotoxin which blocks sodium transport channels for your nerves--it stops your nerves from working.

People with multiple sclerosis, for example, have damaged myelin sheathes, the insulation around the electrical lines in our bodies that we call nerves.

When the myelin sheath is damaged the electrical differential across the nerve diminish and there no longer is enough of a differential to reliably push signals around the body.

So, people in later stages of multiple sclerosis find that their body stutters around like a car engine trying to start with a dead battery.

The neurotoxin TTX doesn't just diminish the electrical differential, however, it stops it.

If there is only a little bit of toxin, your body might process it before you die.

You have 24 hours to live. Live that long and you keep on living.

If not... you don't need to worry about whether you left the lights on; your's will be out.

And not much TTX is needed. Based upon the Sigma-Aldrich (a chemical supply company) Material Safety Data Sheet for TTX it can be calculated that 25 milligrams (0.000881 oz) of tetrodotoxin would be enough to kill a 75 kg (170 lb) person who consumed that much TTX orally.

If TTX was injected into you, say via a pufferfish or blowfish spine, then around half a milligram (0.00002 oz) of TTX would likely do you in.

If you're lucky. though, and survive 24 hours, then you are fine.

Some researchers think that the poison accumulates in pufferfish and blowfish due to a bacteria which they harbour. Others think that TTX is generated by the fish themselves.

An engineer would say... who cares? The fish kills.

The gourmet, however, says... I wonder what it tastes like?

Which was my reaction, years and years ago, on my first encounter, on a two week canoe trip in the Northern reaches of Saskatchewan, on seeing poisonous hemlock. The stuff that killed Socrates.

"I wonder what it tastes like?" I said as I reached out to touch the stuff that had killed Socrates.

And then I reached back to hold my head where the guide, who was in my canoe, had walloped the back of my head with his paddle. (The square root of 64....7?)

I still don't know what hemlock tastes like... nor what the square root of 64 is...

You have no idea how curious I am, too... regarding the taste...

Anyway, back to the pufferfish and to the blowfish.

Handling those fish is tricky.

Filleting one of those fish is also tricky.

Most of the poison is in the organs on the inside, especially in the liver.

One slip of the knife, into an organ, and the poison comes, with the knife, back through the flesh.

Then the eater will likely be dead.

And the chef will be out a job.

My lantern is from the body of a porcupine fish, a blowfish--the one with the bigger spines; it's easier to handle than a pufferfish.

Not only that, but there is slightly less poison in a blowfish than in a pufferfish.

What does that information tell you?

It tells you that if you are going to go to the effort to find and eat one of these fishes, make sure you eat the pufferfish. It's more dangerous and more deadly.

Go for Takifugu rubripes, the torafugu; it's the deadliest and the most expensive.

Only specially trained chefs can prepare and serve fugu in Japan. And it can be quite expensive.

Even when your humble scribe lived in Japan, he never ate it. His girlfriend at the time was against it.

But, like the hemlock, he always wanted to know what it tasted like.

When I lived in Taiwan, I went on an expedition to Penghu (澎湖群島), the archipelago of Taiwanese fishing islands far off the west coast of Northern Taiwan, and very close to Mainland China.

The Portugese called these islands the Pescadores because of the fisherman there and the Portugese found this to be a good place to revictual their ships on their way to the Spice Islands.

The Pescadores were well named; they are excellent for fish and for fishermen.

And, it turns out, for fishermens' daughters.

I found myself in the village headmaster and headfisherman's home.

His daughter had dragged me there and I quite happily went; I knew the food would be fresh.

An aside, I never learned any Taiwanese, besides "I'm full", when I lived in Taiwan.

I could understand some Mandarin, but Taiwanese was completely outside my linguistic abilities.

So, while the girl I was with spoke Mandarin, it never occurred to me that her family would not speak Mandarin.

They only spoke Taiwanese.

The father had invited me, I think, to go out onto the boat all day, that morning.

One look at the choppy waves out the window and I knew that fishing was not in the cards. This girl was great, but she was not the one, and I was not about to slam up and down on that surf.

I wanted to enjoy future dinners, not relive past ones.

Besides, this was my opportunity to hang out in the kitchen with a woman who had cooked seafood her entire life. There would be much I could learn, even if it was all delivered in rapid Taiwanese by someone who still looked astonished that a man would want to hang out in her kitchen.

So be it.

The room had concrete walls, low, squat, snug, and capable of keeping howling typhoons out when typhoons would blow over the island.

The windows were small and shuttered; the light was poor and particles of fat from the morning's cooking hung in the air as they oh-so-slowly coalesced on every surface.

The floor was concrete covered in a peeling linoleum that was curling at the edges. It would have been good for quick cleaning of fish guts with a bucket of water, once.

A small, chipped formica table was the centrepiece of the room, and a hefty round of wood was on that table.

That wood, with deep grooves from countless passes of the knife, was the cutting stump--board or block would be totally unacceptable descriptions for this chunk of tree.

At a glance you could tell where, on the surface, various cutting operations had taken place over the years which was good because direct observation was impossible.

The cooking knife, one singular knife, a fairly hefty cleaver with rust on its thick spine but a wickedly glittering cutting edge, sharpened daily, moved like the wind.

Watching this woman was watching an artisan with decades of experience and generations of learning, but I had no idea what she was doing, or even what she had just done, at any given moment. My knowledge of the knife and its purpose was Heisenbergian at best.

Her craft was one to be learned from the crib, by osmosis.

Nothing was explained; she just had a conversation with me the whole morning. Or, really, with herself.

I never had a clue what she was saying or asking. I just smiled and, eventually, had my own conversation with myself, out loud, in return.

At some point in time the girl woke up and sauntered into the room, surprised that I hadn't left with her Pa on the boat.

But, I'd seen his gaffing stick.

I knew where it was safe, although I would never say that.

Shortly afterwards, she obviously knew the rhythm of the home, her Pa came home. It hadn't been a long trip; I would have been fine. But, how was I to know?

Anyway, Pa strolled into the kitchen, with his rolling gait, and dropped a big bucket of fish, still alive and swimming, onto the table for his wife to prepare, presumably for lunch.

If I hadn't thought his daughter was 'the one' for me, before, it was also obvious that he didn't think I was 'the one', either. But, appearances had to be preserved.

I looked inside the bucket.

Baby octopi filled it.

And little pufferfish.

Pufferfish that looked a lot like Takifugu rubripes, the torafugu.

Wow!

This was going to be great.

Then the preparation began.

First, the mother dipped her hands into the bucket of sea water, pulled up most of the octopi, and dropped them onto the chopping block.

Then she turned and started talking to her husband.

It sounded like she was arguing, but Chinese can sound that way.

The baby octopi, unhappy at finding themselves out of water, were squiggling to the edge of the block, then falling onto the formica table, and spreading out on a mistaken theory that she couldn't get all of them and that some of them would escape.

An aside. If you scuba dive you know that octopi are actually quite shy.


Like a family dog.

They remember you.

I've always had dogs.

I've always remembered my dogs and they've always remembered me.

And I don't eat them.

I eat octopi, but not the ones that I play with when scuba diving.

Watching the octopi kaleidescope themselves around the table was a bit like playing with them.

Except that they were fleeing for their lives.

I was trying to figure out how many I could save and release.

Then the mother turned around, picked up the knife, and decimated the class of octopi as they pirouetted away.

(If fish form schools then the more intelligent octopi must be in classes. You heard it here, first.)

Now I knew why the formica table was so pitted and gashed.

She pointed to the site of the octopi massacre and handed me a plate. I put the grey limbs of the octopi onto the plate as I surreptiously picked out a few bits of formica.

Interestingly, for those who don't live by the sea, octopi are a healthy pinky purpley colour. Until you chop a bit off of them. The second you chop a tentacle off that tentacle becomes grey. Instantly.

I tried to work out the rate of change and the mechanism by watching the main body of each octopi change to grey more slowly in contrast to the instantly grey limbs. Then I realized that the limbs were instantly 'dead' whereas the little baby bodies were dying more slowly of blood loss and oxygen deprivation.

Great. There goes the appetite.

And I can see that Pa brought extra octopi after my capacious belly display of the previous evening.

Fantastic.

As I was doing this, I was thinking about the pufferfish. Or, rather, of the fish that looked like pufferfish.

I know that nobody handles pufferfish in Japan with their bare hands.

People use very thick, special gloves.

And this lady had just dipped her hands in amongst the startled, puffed up pufferfish to grab the octopi.

Damn.

These might not be the real things.

Then, to prove a point, she started to grab pufferfish from the bucket, clean them on that formica table, and fillet them on that big uneven block. With her bare hands. Without looking.

That vorpal blade went snicker-snack. She left them dead, and, with their head, she went galumphing back.

And that lady looked at me the whole time, and carried on her conversation.

So these definitely were not 'real' pufferfish.

Shortly afterwards, her husband and both daughters came into the kitchen.

We all crowded around the table eating fresh octopi dipped in some sauce she had made earlier, and slices of raw not-real-pufferfish.

I tried desperately to follow the dynamics, figure out what was expected of me, figure out which sauce was to go where, and to keep the wandering hand of the daughter at bay as her frankly terrifying father glared at me and sharpened a fearsome fishing blade between using his chopsticks to eat the fish.

I was getting pretty apprehensive about her Pa; he was really giving me the willies.

That knife was giving me the willies, too.

Pa took very few octopi, indicating that there were more for me and that, as the honoured guest, I should be eating up. Or was I trying to let him know that this was not good enough for me?

I don't speak Taiwanese, but some things you just figure out.

Great.

Come here boy.

Woof.

Chew.

Mmmm...

Puppy octopi.

...This was really starting to get to me.

Throughout all this I kept eating the faux pufferfish, trying to make sense of everything going on around me.

I was feeling a bit light-headed from everything going on, not quite dizzy, but almost floaty.

And then I poked the back of my mouth with my chopsticks--hard.

Which is something that you really shouldn't do.

It would be like jabbing the tines of your fork into the back of your throat; bad form.

What type of barbarian can't even use eating utensils?

And then I realized that I couldn't feel my lips.

Or my mouth.

Or my tongue.

Or my neck or shoulders.

And there was a fast, slick, creeping sensation, like a swift slug sliding up towards my eyes, and wiping out my ability to sense anything or feel anything.

That's when I realized that the pufferfish was real.

I also realized that I had a chunk of fish somewhere right beside my trachea, although I couldn't feel a thing.

Like a bit of a madman I forced my lungs to exhale and sent a chunk of fish flying.

Onto Pa.

Who was in mid-stroke of sharpening that blade.

And I gesticulated, as best I could, as my anxiety rose while that invisible slug stole all sensations from me.

...

Well, obviously I survived.

And my paranoia and apprehension, it turns out, were side symptoms of the early stages of pufferfish/TTX poisoning.

And the whole family, apparently, all liked me a lot, especially how attentive I seemed to be to everything, even if our ability to communicate was nil, and even if I was a wimp for sitting in the kitchen rather than going onto the boat.

As to what fugu tastes like? That special Takifugu rubripes, the torafugu?

I haven't a clue.

I didn't think it was real fugu--I was trying to figure out what was going on.

And my tongue and nasal cavity were the first things to be affected.

...Next time...


Tschuess,
Chris

And the music for today is...

Friday, November 27, 2009

On opium

Image of opium smokers in the East End of London, 1874. From the Illustrated London News, 1 August 1874. This image is in the public domain and is sourced from the Wikimedia Commons.
Dear Gentle Reader,

Yesterday was about what might be on the menu for a Hong Kong Thanksgiving, should Hong Kong have a Thanksgiving.

The conclusion which we came to was opium; opium would be the menu, not just on it.

Why?

(Besides the sweetly scented silver derived from the trade, of course.)

Well, lots of great things, like opiate alkaloids, are found in the resin of a few of the plants in the Papaveraceae family.

Today's post continues revolving around Papaver somniferum, the opium poppy.

Opium resin is what you start with.

You get opium resin by lightly slicing the pod of an opium poppy, while it is still on its stalk and attached to the plant, and collecting the white, latex resin that oozes from the cuts.

This resin, collected and dried to a paste, is not a pure, distilled chemical but, rather, a dark smörgåsbord of active ingredients.

The three principal ingredients, from the perspective of a drug taker or a drug seller, are three opiate alkaloids: morphine, narcotin, and codeine.

Morphine, narcotin, and codeine comprise a trinity of soporific delight; a draught of the waters of Lethe without having to get by Charon. Or Cerberus. At least, that is what the seller will tell you...

First though, the naming, as names are so important to poets.

A structural image of morphine's molecular shape.The principal alkaloid, by quantity and effect, in the sticky opium cocktail, is morphine, C17H19NO3.

A structural diagram of morphine is over on the right.

I won't trouble you with diagrams for the next two important opiate alkaloids, Narcotin (C22H23NO7) and Codeine (C18H21NO3).

But, for the fancy bio-linguists out there, the black tie IUPAC names for these three compounds are:

Morphine: (5α,6α)-7,8-didehydro-
4,5-epoxy-17-methylmorphinan-3,6-diol

Naroctin: 6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one

and

Codeine: (5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol

If you are going for any kind of poetry creation, however, I'd recommend staying informal.

It's hard to do a haiku, for example, with any of these fancy IUPAC (International Union of Pure and Applied Chemistry) names.

At least, not while sober.

And sober is not what one stays if you smoke opium.

Technically, of course, opium is not smoked; it is not burned, or it shouldn't be burned. That would be a bit of a waste.

Opium, in an opium pipe, is vapourized.

The smoky fumes, cooling in the long, inclined chamber of the pipe before they reach your mouth, are then inhaled.

I've never done it, but the chemistry and physics of the act are obvious from the engravings of opium dens, and from opium pipes which I have seen in both public and private collections.

Yesterday, we went over the numbers as per the quantity of opium that was being shipped to China even before the British had secured Hong Kong as a port.

A port, you see, was handy.

With a port, like Hong Kong, you could load up on opium in Calcutta and come to Hong Kong to revictual. Further, you could make appropriate arrangements to meet your Chinese distributor somewhere in China.

Who wanted to arrive with tens of thousands of pounds of contraband opium and hang out with the pirates while you try to contact your contact... and then receive cash?

That would be a poor risk management plan...

Further, long range meteorological forecasts were not so reliable. Who wanted to arrive and find out that a tropical storm, or, worse, a typhoon was blowing through the region?

No, a port was a good thing.

A port permitted opium sales to skyrocket, which permitted opium production in India to skyrocket, which in turn allowed British Imperial revenues to skyrocket, too.

Don't just take my word for it. Look at this lovely graph.

(y) tons of opium versus (x) date

Graph and data showing global production of opium, measured in Imperial tons, plotted on a time scale from 1800 to 2000. This graph and data are in the public domain and are sourced from Wikipedia.
As usual, the information on all images is found by rolling your mouse pointer over it. But, for speed, the vertical axis measures global opium production measured in tons. The horizontal axis measures years.

So. What did this mean for for China?

By 1906, 27% of the adult, male population of China was addicted to the lovely cocktail of morphine, narcotin, and codeine found in opium.

Of course, by 1906, the British were, mostly, out of this game.

Most of the opium required to supply 27% of the adult, male population of China, in 1906, was home-grown.

(34,000 imperial tons were produced in China, by Chinese, by 1906, versus Chinese consumption of 39,000 imperial tons.)

But the problems of this many addicts, in China, led to massive social and economic unrest.

By 1911, the unrest would be political, too, as the Qing Dynasty would be overthrown and, in 1912, Generalissimo Chiang Kai Shek would become the President of the Republic of China.

Folks across Asia have bad, and recent, memories of rampant drug addictions.

So, generally speaking, there are significant penalties for being caught with drugs. Especially at entry and exit points...airports or seaports.

(The pessimist would say this is to help safeguard local monopolies in distribution, export, and import. I, of course, would never think such thoughts.)

And here is where the story of the day comes in.

Back when your humble scribe used to live in Taiwan, a very long time ago, an English chap came to Taiwan on business.

He knew about the concept of giving gifts, to help generate better relationships with people.

So he brought a dried flower arrangement.

(I know. I don't think he knew much about giving gifts, or relationships. But, I guess, he tried. Or maybe his secretary hated him.)

So what?

That arrangement contained a dried poppy.

Not, I hasten to add, an opium poppy, Papaver somniferum.

Just a regular, run of the mill poppy.

...

It took weeks for him to be sprung from prison on Green Island.

Green Island has a prison and not much else.

This is a prison where, then at least, your family and friends had to send you food if you wanted to maintain a vaguely appropriate caloric intake.

Or, if you wanted to try to bribe the giant rats so that they wouldn't nibble on you nose or gnaw on your shins when exhaustion overcame you.

Now there was a man who, I am sure, would have wanted a long, deep draught from the waters of Lethe, or from our unholy trinity of opiate alkaloids, when he was finally released.

Asia.

Don't mess around with things you shouldn't.

And be thankful for everything that you do enjoy.

But, try to not need opium.

Things could always be worse.


Tschuess,
Chris

P.S. I am thankful that you are reading. Go figure. That surprises me every day.

P.P.S. Why does your humble scribe know anything about opium?

I have taken on the alter-ego of an Akkadian scribe...

And Sumerian pottery was being decorated with opium poppies before cuneiform was fully developed as a script for language, not just for accounting for profit and loss.

It's in my collective memory, if not my blood (thank goodness). Take care.

For music, today, Karl Marx thought this stuff was the opiate of the masses; I am quite happy to imbibe an opiate like this.

This is the first movement in an Armenian liturgical concert.


Click to hear 'Where are you, oh Mother' by Isabel Bayrakdarian
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Tschuess,
Chris